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-synuclein, that's a principal part of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and brings about endoplasmic reticulum (ER) pressure, counsel that dysfunction with the intracellular proteinase devices, including ubiquitin-proteasome process or lysosomal method, which gets rid of unnecessary toxic
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